Biphasic mural proteolysis in atherogenesis

True bacterial mural endocarditis.

existed with the pulmonary venous anomaly was considered. Resection of the left lower lobe was contemplated. Based upon careful palpation of the entire lung and presumptive evidence that the preoperative roentgenogram and the operative findings coincided, the decision not to resect was made. Delayed postoperative pulmonary angiography (Fig 2) confirmed the validity of this decision. Anomalies o...

Ferns and Heikal, Atherogenesis and hypoxia Hypoxia in Atherogenesis

The anoxemia theory proposes that an imbalance between the demand for, and supply of, oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism and responses of many of the cell types found wi...

Proliferative Mural Bronchiolitis.

The microcirculation in atherogenesis.

The term ‘atherosclerosis’ is generally employed for a disease process characterized by the formation of atheromas (fibrofatty intimal plaques) resulting in progressive hardening of the arterial wall, loss of vascular elasticity, and luminal compromise. Different segments of the vascular tree vary in their susceptibility to develop atherosclerotic lesions: atheromas have been described characte...

Hypoxia in Atherogenesis.

The anoxemia theory proposes that an imbalance between the demand for and supply of oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism, and responses of many of the cell types found wit...